Multistorey RC framed buildings, irregular in plan, often exhibit unfavorable seismic behaviour. In this study, the influence of the earthquake incidence angle on the seismic response of irregular RC framed buildings is examined. Three multistory RC buildings, One regular in plan and Two plan irregular buildings (C-shape, L-shape) are investigated for critical seismic incidence angle. For a good comparison, all the three buildings having the same floor plan area are modeled. The Linear Time History Analysis (LTHA) has been carried out for these three buildings by considering the twelve different earthquake directions and rotating the direction by 15o for each analysis, ranging from 0o to 180o. All these three buildings are modeled using ETABS Software and are subjected to Northridge earthquake accelerogram. It is observed from the study that, the seismic behavior of these three buildings is considerably influenced by the seismic incidence angle. The various parameters observed in this study are axial forces in columns, storey drift, storey shear and maximum storey displacement. The results reveal that the direction of earthquake incidence angle considerably influences the response of multistorey RC buildings