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Network Biology Approaches for Functional Gene Module Discovery: Tools, Techniques, and Applications in Functional Genomics

Pankaj Gupta*, Sanjay Mishra**, Ragini Yadav***, Prianshu Singh****, Charu Srivastava*****, Niharika Pandey******, Mohammad Ahmad*******, Varun Kumar Sharma********, Manoj Kumar Mishra*********

*-******* Department of Biotechnology, SR Institute of Management and Technology, Lucknow, Uttar Pradesh, India.

********-********* Department of Biotechnology and Microbiology, School of Sciences, Noida International University-NIU, Gautam Budh Nagar, Uttar Pradesh, India.

Periodicity:September - December'2025
DOI : https://doi.org/10.26634/jls.4.3.22550

Abstract

Functional genomics aims to understand the dynamic aspects of gene expression and function at a systems level. Network biology offers a powerful framework to uncover functionally coherent gene modules by integrating various types of biological data. This review summarizes the current tools and computational techniques used for functional gene module discovery, highlighting their theoretical foundations, strengths, and limitations. Recent advances in integrating multi-omics data, single-cell analyses, and the application of machine learning are also discussed. Emphasis is placed on the biological relevance and translational potential of identified gene modules in areas such as disease mechanism elucidation, biomarker discovery, and therapeutic target identification.

Keywords

Network Biology, Functional Gene Modules, Functional Genomics, Multi-Omics Integration, Gene Co-Expression Networks.

How to Cite this Article?

Gupta, P., Mishra, S., Yadav, R., Singh, P., Srivastava, C., Pandey, N., Ahmad, M., Sharma, V. K., and Mishra, M. K. (2025). Network Biology Approaches for Functional Gene Module Discovery: Tools, Techniques, and Applications in Functional Genomics. i-manager’s Journal on Life Sciences, 4(3), 29-37. https://doi.org/10.26634/jls.4.3.22550

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Network Biology Approaches for Functional Gene Module Discovery: Tools, Techniques, and Applications in Functional Genomics

Abstract

Keywords

How to Cite this Article?

References

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