Significant structural collapses happen when a structure is exposed to dynamic loads, such as wind and earthquake loads. The majority of contemporary buildings include architectural meaning, which makes regular form planning extremely challenging. When dynamic loads cause a building to collapse, these anomalies are to blame. It is recommended that all structural analyses be carried out using the ETABS software package to accurately obtain displacement values and other structural responses. With the literatures the current study summarizes the Marcos 3-D of G+20 floors with asymmetric vertical configuration starting on the ninth level and symmetric lifting arrangement throughout its height determining the answers of every prior table for every possible combination of loads. The dynamic analysis is authorized by IS 1893 (Part 1): 2016, and the response spectrum analysis method is recommended to determine the lateral forces and shear demands on the floors of the three building models resulting from seismic loads (analysis of linear dynamics). The impacts of dough inconsistency and vertical irregularity under dynamic stresses in multi-story buildings were highlighted in this study. Three reinforced concrete (RC) building frames have been selected for the study, and it is recommended that each frame be individually modeled and analyzed in detail.