In Vitro Anticancer and Antioxidant Activity Screening of Selected Marine Micro Algal Extracts

Rahul Pratap*, M. L. Lal Prasanth**, Anu V.***
*-*** Dr. Moopen's College of Pharmacy, Kerala, India.
Periodicity:January - April'2023
DOI : https://doi.org/10.26634/jchem.3.1.19293

Abstract

The present study was aimed to evaluate the anticancer and antioxidant activity of the five algal samples named as S–1 to S–5 isolated from the seawater collection of Muttom coastal region of Kanyakumari District. Mass production of micro algae was done by using sea water containing Walne's medium and each cultivated algae was isolated by centrifugation and extracted with different solvents viz., ethyl acetate, methanol and water. The extracts obtained were evaluated for in vitro anticancer and antioxidant activity. Anticancer activity was evaluated by MTT assay using the cell lines MCF7 and SKMEL. In this evaluation, extracts of all the algal samples showed anticancer activity against the selected cell lines, however, the methanol extract of S–2 sample showed significant activity comparing with other samples. Antioxidant activity was evaluated by DPPH, reducing power assay and superoxide radical scavenging assay methods. In this evaluation also, the methanol extract of S–2 sample showed a significant antioxidant activity in all the tested methods. These results are useful for further investigation in the future.

Keywords

Marine Microalgae, Extraction, Anticancer Activity, Antioxidant Activity.

How to Cite this Article?

Pratap, R., Prasanth, M. L. L., and Anu, V. (2023). In Vitro Anticancer and Antioxidant Activity Screening of Selected Marine Micro Algal Extracts. i-manager's Journal on Chemical Sciences, 3(1), 6-11. https://doi.org/10.26634/jchem.3.1.19293

References

[6]. Kumar, K. A., Manickam, M. S., Sreejith, M., & Sebastin, V. (2021). In Vitro antioxidant and anthelmintic activity of the extracts of whole plant crotalaria biflora (L). Annals of the Romanian Society for Cell Biology, 25(4), 150-161.
[10]. Mathan, S., Smith, A. A., Kumaran, J., & Prakash, S. (2013). Anti cancer activity of n-butanol extract of marine sediment fungi Aspergillus protuberus sp1 against dalton's ascitic lymphoma in mice. Journal of Pharmaceutical Sciences and Research, 5(3), 76-79.
[14]. Saranya, C., Hemalatha, A., Parthiban, C., & Anantharaman, P. (2014). Evaluation of antioxidant properties, total phenolic and carotenoid content of Chaetoceros calcitrans, Chlorella salina and Isochrysis galbana. International Journal of Current Microbiology and Applied Sciences, 3(8), 365-377.
[16]. Sebastin, V., Gopalakrishnan, G., Sreejith, M., & Kumar, A. K. I. (2021). Determination of total phenolic content and antioxidant activity of the whole plant extracts of Argyreia imbricata (Roth) Sant. & Patel. International Journal of Research in Pharmaceutical Sciences, 12(1), 919-925.
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