Children with developmental delays often display a greater number of problems than typically developing children. This has been linked to elevated stress in their parents. Coping strategies can potentially strengthen or maintain resources that serve to protect them from the demands of stressful encounters. To measure the degree of stress and coping experienced by the mothers of children with developmental delays and to assess the impact of an intervention package on stress and coping, respectively. A quantitative research approach with a quasi-experimental pre-test and post-test control group design was used for the study. The framework, Betty Neuman's system model, theoretically supported the study. The study was conducted among sixty mothers of children with developmental delay attending the Regional Early Intervention Centre, and the mothers were selected by nonprobability purposive sampling. The tools used for the data collection were socio personal and clinical data sheets, a stress rating scale for assessing stress, and a maternal coping scale for assessing coping among mothers of children with developmental delay. The data collected was analyzed using descriptive and inferential statistics. Data analysis revealed that the intervention package significantly reduced stress and improved coping among mothers of children with developmental delays. The current study revealed that, the intervention package was effective in reducing stress and enhancing coping among mothers of children with developmental delay.