In this present study, an effect of floor plan shape on seismic response of base-isolated buildings, linear modal time history analysis has been done on 9 models of 15 storey building. The modelling consists of different floor plan shapes buildings such as square shape plan, rectangular shape plan and H-shaped plan building with varying base such as fixed base, lead rubber bearing and friction pendulum system respectively. The Time History Analysis (THA) has been done on the base near fault ground motion dataof El Centro city taking IS 1893: 2016 into consideration. The seismic zone V and soft soil is selected for the THA of all the models. The modelling and analysis has been done with the help of software ETABS version 17.0.1 and the responses recorded are such as maximum storey displacement, maximum storey drift, maximum storey acceleration, maximum base shear, maximum absolute joint acceleration at the joint 1 of the top storey and modal time period. The responses recorded are compared on the basis of similar plan shapes with the different bases. As we all know that the population is growing extensively, so the need of multi-storey residential buildings is also increasing and hence they are exposed to seismic destruction in earthquake prone zones. In this study, efforts has been made to conclude how effectively LRB and FPS reduces such damages so that a structural engineer can enhance the stability of the structure and can save valuable life and money in earthquake prone zones.