Nursing is a distinctive profession that requires comprehensive understanding based on theoretical knowledge of the discipline. The "Notes on Nursing" is the extensive work, proposed by Florence Nightingale which offers the concept of sanitary nursing by suggesting that the safe, clean, and curative environment could enable nature to influence a curative process. The objective of this paper is to correlate the assumptions, concepts, and sub-concepts of Nightingale's theory with the patient's clinical scenario. Moreover, the paper will further analyze the scenario through the propositions of the theory which tends to prevent unpleasant outcomes while caring for a patient. To conclude, grounding strongly to the theoretical concepts of nursing tends to transform the nurse's approach of planning patient's care, efficiently. Lastly, multiple recommendations would be implemented to build the skills as practitioners, advocates, and influential leaders in the health care setting.