Chronic Kidney Disease (CKD), such as End-Stage Renal Disease (ESRD) has the most devastating impact on the life expectancy of the renal patients. CKD and its complication have an impact on the quality of life of the patient and their families. CKD patients stay miserable at the hospital and it leads to psychological stress. Heath Care Professionals (HCP) face ethical dilemmas recurrently, while dialyzing the hemodialysis patients. The cost of the hemodialysis procedure also impacts on the patient’s social life and also the financial and other contributing stressors lead to delayed behavior and noncompliance. There is a role of the nurse for continuous reinforcement of education with the support group to help the patient to deal with these situations. This paper will discuss the scenario and an ethical dilemma that we face routinely in the light of theory of liberal individualism. The principles of ethics should be considered, which are beneficence and nonmaleficence to anyone without compromising care. Ongoing reinforcement has a vital role for the non-complaint patients and tardy behaviors might consequently end up in mortality and morbidity. Innovative strategies should be incorporated to provide proper and relevant treatment, to save resources and provide compassionate care with critical thinking. A multi-disciplinary team should be involved to ensure sound decision-making in such situations. Moreover, nurse vigilance and interventions beyond the horizon could make a great difference.