The accomplishment of a basic microbiology course is a solid indicator of how students will perform in further nursing courses and clinical areas. The students should give special attention to a microbiology course in the nursing school. A good nurse must have a sound knowledge of basic microbiology to integrate her knowledge in clinical practice. Nurses who are working in the hospital settings mostly use their knowledge for infection control, hospital-acquired infection, disease transmission and control of microorganisms. Those who are working mostly in community settings utilize their microbiology knowledge in the collection and handling of specimens, understanding the medically important microorganisms, and combating infection in the immune-compromised host. In the case of clinical setting, nursing students lack the knowledge about the infection control which may make them exposed to infectious organisms. Therefore, there should be some educational strategies to enrich their ability to utilize this exposure effectively.