The current investigation briefs the need and importance of deep tech start-ups in a rapidly advancing world, especially in the context of India aiming to achieve developed nation status by the year 2047. The initiatives taken by the Government of India for giving birth to deep tech startups are outlined in brief. Deep tech startups essentially require higher education institutes and universities to become entrepreneurial and innovative for generating advanced breakthrough and disruptive technology so essential for spinning off deep tech enterprises. The changing role of universities and their becoming entrepreneurial in the new world is also presented. Academic and political leaders need to take necessary action for shaping them to spin off deep tech startups. It also describes the characteristics of entrepreneurial universities elsewhere in the world, which are known for giving birth to deep tech startups. Universities becoming entrepreneurial demands a change in mindset of Indian academic and political leaders. Will they change their mindset? They ought to realise vast new opportunities in the world for employment, increase in GDP and harvesting them through deep tech startups. The paper presents new visions & missions derived from world-ranking entrepreneurial universities that need to be adopted and implemented in Indian universities. Organisational structures like advanced research labs, research parks, technology incubation centres, and patent & IPR centres would have to be installed forthwith on university campuses. Curriculum in universities would have to be orientated to creativity, discovery, and commercial exploitation of deep technology. Lastly, the paper also brings out in brief problems in the adoption and implementation of deep tech startups in present Indian conditions. Success depends on whether India will be able to make its universities entrepreneurial in global comparison.