Secondary school science education is evolving to meet the demands of the 21st century, with innovative teaching strategies, technology integration, and policy reforms creating more engaging and effective learning environments. Enhancing science education is essential for fostering a scientifically literate society capable of addressing future challenges. Knowledge Integration (KI) is a research-based pedagogical approach that enables students to combine new scientific ideas with prior knowledge to form coherent conceptual frameworks. Through this process, learners connect diverse concepts, reorganize existing understandings, and apply integrated knowledge to complex problems. This study examines the relationship between established and emerging knowledge, highlighting how structured connections, active reasoning, and reflective opportunities promote deeper scientific understanding. By engaging students in inquiry, interdisciplinary connections, and metacognitive reflection, KI fosters critical thinking, problem- solving skills, and long-term retention. The findings underscore the potential of KI-based instructional strategies to transform science learning and prepare students to think, reason, and act like scientists.