A contract research organization (CRO) works like an employed agent in the healthcare field with consistent information, understanding, and capability to manage and complete duties for the sponsor. The progressive growth and extent of sponsored subcontracting work has made this for-profit money making business in the earlier time. The patient-focused approach in drug discovery is used through balanced data created through CRO's services. This article points out the need to study the evolution and the current flow pattern of the CRO industry, its market size, and statistical reports highlighting the major firms and to discuss the pros and cons of the CROs. And trial and the efficiency to understand the prospects for augmented trial designs and results to reduce development costs.